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Notably, the origin and fate of acetyl-CoA are key factors that help distinguish between M1 and M2 ( Figure 1 Figure 2 In a nutshell, pro-inflammatory M1 macrophages are metabolically characterized by a high reliance on aerobic glycolysis and present two key breaks in the TCA cycle, leading to the accumulation of citrate, succinate, and itaconate
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Post-inflammatory hyper/hypopigmentation may occur in darker skin types and persist for up to 6 months
Flushing and a warm face are also common
