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Collagen peptides could activate the transforming growth factor-beta (TGF-)/Smad pathway and inhibit the expression of activator protein-1 (AP-1), matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-9 [34], thereby reducing collagen degradation and promoting collagen synthesis and the repair of photoaged skin cells

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One such example is the class of MIAs, which are biosynthesized through the universal precursor strictosidine ( 50 )

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