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Drug Des Devel Ther (2020) 14:410113

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Pitolisant's efficacy could be mediated through its activity that increases the synthesis and release of histamine in the brain via competitive binding to presynaptic histamine-3 autoreceptors

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Significantly upregulated or downregulated proteins were used as the foreground, and all measured proteins in the liver were used as the background

Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)