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ZEA is a nonsteroidal, estrogenic mycotoxin and has been shown to be able to bind competitively to estrogen receptors [3]

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In severe cases, the thumb may be completely dislocated

Cell Death Dis 10:449 Yang W, Liu X, Song C et al (2021) Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

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These metabolic disturbances arise from disorders in iron absorption, transport, storage, and utilization, influenced by various external factors, diet, intestinal function, genetic predispositions, abnormalities in key proteins, changes in iron storage forms, and iron utilization disorders, all of which interact to contribute to PF (Li et al., 2021b)