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Protein hyperacetylation has been observed in the failing hearts of patients and animal models suggesting that decreased sirtuin function may be a pathogenic mechanism in heart failure [32, 6164]

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Plasticity of perisynaptic astroglia during ischemia-induced spreading depolarization

Dimethyl fumarate (DMF) and its metabolite monomethyl fumarate (MMF) modulate some signaling proteins activity and intracellular concentration, such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), nuclear factor-kappa B (Nf-B), and cyclic adenosine monophosphate

CDPI shows several advantages over the nebulized solution form, including shorter administration (1 min) and an enhanced portability (Conole and Keating, Fluoroquinolones Fluoroquinolones belong to the family of quinolones, a group of molecules that is widely used as antibiotic because of their large spectrum of bactericidal activity, excellent bioavailability, rapid cellular uptake (Drusano, 1999) and tolerance (Grillon et al., 2013)