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Nat Commun 12(1):224 2021 PMC7801645 Sabatini PV, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp AC, Adams JM, Wang J, Beck Jorgensen S, Olson DP, Palmiter RD, Myers MG, Jr., Seeley RJ

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We recommend 1-3 capsules, 1-2 times daily

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A 2024 Cochrane Database review of five clinical trials included 984 pregnant women from low- and middle-income countries (including India, Bangladesh, South Africa, and Croatia) in which 26% to 51% had vitamin B 12 deficiency (less than 150 pmol/L) and 30% to 46% had anemia (hemoglobin less than 11.0 g/dL) at enrollment (88)