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CX516 is a positive allosteric modulator that potentiates glutamate activation with the final outcome of strengthening synapses (ONeill et al., 2004

Additionally, GABAergic neuron excitability in PD is increased at the dopaminergic D2 receptor but decreased at the D1 receptor, indicating an imbalance between the direct and indirect pathways

This project was supported by a Stanford Medicine Discovery Innovation Award to Dr

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They are expressed in vasculature, kidney, brain and heart [30]