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Human primary neutrophils were treated in the same manner, except that PMA stimulation was performed at 5 nM for 4 h

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For severe deficiency, patients get 1,000 mcg daily for the first week

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It represents about 2/5 of the remaining portion of the small intestine below duodenum

While the drug showed significant therapeutic effects in phase II/III induction therapy for ulcerative colitis, it failed to demonstrate clinical efficacy in phase II trials for Crohn's disease [392]
