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Safety and precautions: Because pure bacteriostatic water is hypotonic, it should not be injected alone intravenously (doing so can cause red cell hemolysis)

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Widespread use of DOACs began in 2010 due to multiple factors, including 421 : Standardized dosing Decreased frequency of follow-ups Less adverse effects Fewer medication and food interactions Quicker onset of action Because of these factors, DOACs are generally preferred over warfarin by both patients and physicians