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Heliyon 10, e29654

doi: 10.1126/science.aad9642 Summary Keywords epilepsy, mitochondrial complex, coenzyme Q, cytochrome C, genes Citation Zhang X, Zhang B, Tao Z and Liang J (2025) Mitochondrial disease and epilepsy in children

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SIRT1 suppresses AP-1 transcriptional activity and its downstream inflammatory mediator, cyclooxygenase 2 (COX2), by deacetylating PGC-1, thereby exerting anti-inflammatory effects [39]