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NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2M) and can selectively bind to NNMT substrate binding site residues

Weakened immunity: Impaired T-cell function and macrophage activity

J Clin Endocrinol Metab 86 : 58135818 Zick Y (2004) Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

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