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These transporters have a finite capacity that becomes saturated at higher doses, consequently causing absorption efficiency to decline sharply

However, medical studies have indicated adverse side effects of Nexium when taken for the long-term, including kidney disease and renal failure

Expert Opinion on Pharmacotherapy 2010;11(2):24956

Malabsorption: This can result from various conditions affecting the gastrointestinal tract, such as Crohns disease, celiac disease, gastritis, surgical removal of parts of the stomach or small intestine, and certain medications

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Physical examination may reveal pallor, glossitis, neurological signs such as reduced vibration sense or proprioception, and in advanced cases, ataxia or cognitive impairment