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Louvet A, Mathurin P

A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease

utilized 4-phenylbutyrate (a potential PFIC2 treatment) in BSEP-deficient hepatocyte-like cells and found that the level of BSEP expression and the calculated biliary excretion index were preserved

doi: 10.21037/tcr-21-227 112 ShiMZhangMJYuYOuRWangYLiHet al

Post-traumatic cervical kyphosis in children cannot be prevented by non-operative methods

Based on these findings and on the consideration that the negative results of gene mutations in Hiroshima and Nagasaki might be caused by erroneous methodology, these authors concluded that radiation-induced persistent accumulation of genomic instability may cause various disorders in a further generation in humans [223]