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Glutamate was a potent inhibitor of the cystine uptake throughout the experiment, indicating that A2780DDP cells preserve most of the system x c activity for at least 6 months in the absence of CDDP treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] 630

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Extensive human trials are required to validate whether these algorithmically predicted neoantigens can consistently overcome immune tolerance and trigger effective anti-tumor responses in patients

NAD + is consumed by various enzymes, generating NAM as a byproduct, which can either be recycled or methylated to 1-methylnicotinamide (MeNAM), removing it from the NAD + pool

[DOI] [PubMed] [Google Scholar] 42.Breslow MJ, Min-Lee K, Brown DR, Chacko VP, Palmer D, Berkowitz DE