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Importantly, these effects were achieved even though treatment was not initiated until 18 mo of age

On the other hand, the tightly regulated and stable phenotype of normal cells, compared to cancer cells, may render them less responsive to signals from TIS, possibly resulting in a limited pro-proliferative effect on non-cancerous cell types

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doi: 10.3390/ijms242216467 19 HouMJHuangXZhuBT

Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development