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Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases

Webster, S

Theranostics (2020) 10(11):510719

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The importance of identifying PsO patients at elevated risk of progressing to PsA arises from the observed disparity in treatment efficacy vs cutaneous signs, wherein fewer than 50% of patients achieve clinical remission once PsA has been established.4 These circumstances drive research into the feasibility of preventing PsA development or intercepting its progression.5 Given the established correlation between PsO severity and PsA risk,3 several investigations have explored the prospect of aggressive systemic therapies, such as biologic therapies, as potential preventive measures vs PsA development.1,613 In the current landscape, biologic therapies represent some of the most effective therapies for PsO

Adequate folate levels are essential for neurotransmitter synthesis, such as dopamine and serotonin, and regulation of homocysteine levels, the latter linked to neurodegenerative disorders (, )