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A mutant 2 AR in which all the phosphorylation sites are altered, such that there is no agonist-induced phosphorylation, shows impaired ubiquitination as well as significantly reduced -arrestin interaction [70, 80]

This transformation involves increased or de novo expression of adhesion molecules, including E-selectin, P-selectin, intracellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) (Knottnerus et al., 2009)

The T-tubules are likely to represent the major site of glucose uptake in response to insulin stimulation since it has been shown that the majority of mobilized GLUT4 transporters are inserted into the T-tubule membrane
Hence, it remains to be determined whether increases in circulating bilirubin predispose to or maybe increase sports performance

Nature 475 , 497500 (2011)