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Interestingly, simultaneous deletion of FOXO1 and TSC1 from livers lacking AKT completely restored lipogenesis in vivo , independent of increased Insig2a expression, indicating that the AKT-FOXO1 signaling axis may additionally regulate DNL (325)

Cpt1a Promoted ROS-Induced Oxidative Stress and Inflammation in Liver Injury via the Nrf2/HO-1 and NLRP3 Inflammasome Signaling Pathway