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ROS induces the accumulation of excess lipids and the formulation of growth factors, including TGF-, vascular endothelial growth factor (VEGF), and inflammatory factors, which are essential factors that lead to renal dysfunction and subsequent nephropathy.ROS mediates HMGB1/mitochondrial DNA signaling, promotes TLRs activation and inflammatory responses, and exacerbates EMT in proximal renal tubular epithelial cells (82) ( Figure 1 )

It is somewhat paradoxical that elements essential for life (notably oxygen) can harm the human body through these reactive species (Lobo et al

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