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Although direct aldehyde modification of HuR by 4-HNE has not been definitively confirmed, multiple studies have shown that 4-HNEinduced oxidative stress activates signaling pathways that regulate HuR phosphorylation and dephosphorylation, significantly increasing its binding affinity for inflammatory mRNAs

Rome: Food and Agriculture Organization (2001)

More significantly, it provided a mechanism capable of accounting for all cases of the disease

Sainz et al., 2015

4.2.2 Serendipita vermifera This fungal root endophyte exhibits inter-kingdom synergistic effects with the microbiota in Arabidopsis thaliana and barley (Sarkar et al., 2019)

Those of you familiar with CAN probably have these questions after reading the previous paragraphs, as CAN itself does not really support these features - so how does CANopen do it