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Beyond using sertraline in combination with radiotherapy as a therapeutic strategy for ser/gly synthesis dependent cells in normoxia, the hyperactivation of ser/gly synthesis enzymes under hypoxia in NSCLC also suggests the potential of sertraline to target hypoxic cells relying on ser/gly synthesis (Figure S11)

10.1007/s00439-019-02031-7 139 WoodsA.DickersonK.HeathR.HongS

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This relationship must remain stable across individuals, device lots, and varying environmental conditions throughout the sensors operational lifetime

Experimentally, BSO has been widely used to induce GSH depletion (hence increase redox potential +30mV at 100M BSO for 24hrs in HeLa cells [37]) due to its inhibitory effects on GCS production, the rate limiting enzyme in GSH synthesis [38]

Magnesium deficiency, also known as hypomagnesemia, is often recognized as a health issue that can be overlooked