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Overall, however, the transsulfuration pathway appeared more active in cells expressing WT MTAN, especially given the higher concentrations of cysteine and GSH, which were probably due to the increase in SAM observed under the same conditions (Supplementary Fig

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Glutaminolysis fuels the TCA cycle and subsequent oxidative phosphorylation (OXPHOS) in mitochondria, we therefore determined whether combined inhibition of LDHB/SLC7A11 leads to abnormal respiration and energy production in mitochondria

GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms