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Moreover, BH4 can be regenerated by dihydrofolate reductase (DHFR)

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ROS is a core factor in regulating both cellular and physiological functions by affecting various signaling or acting as a signaling molecule

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Therefore, multiple inhibitions of controlling steps of other energy metabolism pathways, such as glycolysis and glycogen metabolism, as well as inhibition of the antioxidant system or mitophagy, might be a strategy to avoid the induction of compensatory mechanisms to prevent drug resistance