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Our non-targeted metabolomics study did not set any prior assumptions about DR's effects and generated a hypothesis of increased phase II reactions based on the identified markers in larger number of animals ( n = 8 for control and 13 for DR)

The steps involved in glucuronide synthesis are depicted below: where X = O, COO, NH or S

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Through this review, we aim to inform the readers of recent approaches for managing obesity and comparing their beneficial effects and efficacy on obesity and its long-term co-morbidities