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[1] [2] As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide enhances insulin secretion, suppresses glucagon release, and slows gastric emptying to improve glycemic control and promote weight loss

Hormonal and blood-sugar disruption, including elevated cortisol and prolactin, reduced insulin sensitivity, and hypoglycemia risk tied to IGF-1 receptor activity

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Senotherapeutics may also accelerate liver fibrosis, a particularly significant concern for patients with liver injuries [142]

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GHK-Cu works through cumulative gene expression changes, not acute blood levels