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doi:10.1042/BJ20042015

Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death

[DOI] [PubMed] [Google Scholar] 2.Okonek S, Hofmann A, Henningsen B

Serine is first converted to glycine via the mitochondrial serine hydroxymethyltransferase 2 (SHMT2) catalyzed reaction

analysis 39 (5), 951955

However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)