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Isatuximab interacts with a discontinuous epitope partially overlapping the catalytic site, whereas Daratumumab binds to two continuous amino acid sequences situated outside the enzymatic active site of CD38 (52, 53)

Atreya, I., Atreya, R

426 The activation of Ras is predominantly driven by ligand binding to receptor tyrosine kinases (RTKs) rather than GPCRs

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