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Notably, NMDAR-dependent activity has been shown to directly regulate activity-dependent CCK release [55], and NL3 dysfunction disrupts postsynaptic NMDAR localization and NMDAR-dependent synaptic activity [56], potentially perturbing this developmental regulatory process

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Moreover, GHK-Cu significantly inhibited the LPS-induced phosphorylation of p38 MAPK and slightly decreased the phosphorylation of JNK1/2, while having no observable effect on ERK1/2

In the brain, extracellular Glu content is maintained at extremely low levels because Glu may exert excitotoxicity in some neurons expressing NMDA-type glutamate receptors [163]
