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FDA-approved weight loss medications like semaglutide (Wegovy) and tirzepatide (Zepbound) have undergone large-scale clinical trials demonstrating statistically significant weight loss

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Our enhanced understanding of the gut-brain axis, and its modulation via GLP-1 drugs, manipulating the gut microbiome and its metabolites (reviewed here), or through neural pathways, holds exceptional promise for a new era of medicine largely unforeseenthat is centered on our gut