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Patients with HT who received replacement with levothyroxine (L-T4) did not always achieve clinically significant results, which requires additional therapeutic agents ( The significant prevalence of AITD, a long latent period and the involvement of autoimmune processes in their occurrence, development of concomitant diseases, insufficient effectiveness of the main pharmacotherapy, and a decrease in the quality of life of patients require the development of adequate approaches for the correction of immune processes in order to prevent and treat diseases

Clinical implications of NcRNA dysregulation in infertility Emerging translational research demonstrates that specific ncRNAs act as molecular fingerprints of infertility, detectable in easily obtained clinical specimens such as seminal plasma, spermatozoa, follicular fluid, granulosa cells, endometrium, and circulating extracellular vesicles

ALCAR and KET increased rCMRglc at similar degrees in prefrontal, somatosensory, and cingulate cortices, and KET increased rCMRglc at a different, much larger, degree in limbic and dopaminergic areas