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Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion

In MOUNJARO placebo-controlled clinical trials in adults, acute gallbladder disease (cholelithiasis, biliary colic, and cholecystectomy) was reported by 0.6% of MOUNJARO-treated patients and 0% of placebo-treated patients

Spine J 14(1):65-72, 2014

COX-1 is constitutively expressed in most tissues and produces prostaglandins for physiological housekeeping gastric cytoprotection (PGE2 and PGI2 protecting the gastric mucosa), platelet aggregation (TXA2 in platelets), and renal blood flow maintenance (PGE2 and PGI2 in the kidney)

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This is notable because shifts in calcium homeostasis are claimed to be involved in AD pathogenesis [120, 121]