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A hallmark of NDDs is the accumulation of toxic protein aggregates in the brain

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There are also pleiotropic effects of some compounds which indirectly re-activate survival pathways (e.g., compensatory activation of other RTKs or augmented antioxidant defenses) which can suppress the net anticancer effect, and in extreme circumstances can temporarily maintain the survival of stressed malignant cells

The goal is to ensure intravenous support is offered only when appropriate and likely to provide meaningful benefit