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PGC-1 is a regulator of mitochondrial biogenesis, promotes ATP production, and reduces oxidative stress to create an intracellular environment that promotes BDNF synthesis and secretion

Briefly, 6 hpf embryos were transferred singularly into 24 well plates (1 embryo in 1 mL solution/well) and incubated with increasing concentrations of BSSG (2.55102040 M) or the corresponding solvent control (DMSO at 0.1%0.2%0.4%)

(2000a)

doi:10.1007/s43032-022-01126-3

Collectively, these findings underscore a pathogenic synergy wherein -syn aggregation and lipid peroxidation co-amplify each other, culminating in ferroptotic cell death and neurotoxicity

Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW