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The oral administration of NPT200-11 resulted in brain concentrations of 10 mg/kg, but this increased availability in the brain did not translate into a significant improvement in the symptomatology compared with that of the original molecule [320]

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Conclusion: Recognizing and Addressing Low Brain Folate in Autism and Neurological Disorders Low brain folate due to folate receptor autoantibodies (FRA) is a frequent but often overlooked condition, especially in autism, seizures, and other neurological disorders