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Although the capability of SANS to selectively analyze a query protein using contrast variation and specific deuterium-labeling seems to be particularly powerful for investigating IDPs within complex, biologically relevant environments that mimic cellular conditions, this method was not broadly applied in IDP analysis until quite recently (Gabel, 2012) and therefore did not contribute much to the establishing of the IDP field

13) Unknown Long-Term Safety Profile The most significant safety consideration is the absence of long-term human clinical trials

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