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Cellular uptake experiments: 200 nmoles aliquots of targeted and non-targeted liposomes were added to an invitro model of blood brain barrier (co-cultures of rat astrocytes and bovine capillary endothelial cells) as well as to single cultures of BCECs

Injection-Based Administration Subcutaneous injections: All GLP-1 RAs are administered via subcutaneous injection Prefilled pens: Most common delivery system, allows for self-administration Auto-injectors: Simplify the process for patients with dexterity issues Multi-dose pens: Require dose dialing and needle attachment Dosing frequency: Daily: Liraglutide (Saxenda, Victoza), some formulations of exenatide (Byetta) Weekly: Semaglutide (Wegovy, Ozempic), tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide extended-release (Bydureon) Titration schedules: Most FDA-approved GLP-1 RAs require gradual dose escalation to minimize gastrointestinal side effects

However, 600 mg per day of magnesium when given alone, and 400 mg per day of riboflavin when given alone have each been shown in double-blind trials to be effective for migraine prophylaxis