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In a nested case-control study using a UK primary care health record database that measured MASLD prevalence from clinical coding, there was a 54% elevated risk of MASLD in women without a history of HRT use (OR 1.54, 95% CI 1.33-1.77) but only a 15% elevated risk of MASLD in women who were using HRT (OR 1.15, 95% CI 1.02-1.30) (125)

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Reactive oxygen species (ROS)including the superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH)are natural byproducts of aerobic metabolism