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Whether administered 1, 3, or 5 hours before ventilation (pretreatment) or at different time points after ventilation (post-treatment), H 2 S inhalation effectively reduces pulmonary edema, histological damage, neutrophil infiltration, and ROS generation ( 2 S exerts pulmonary protection by synergistically inhibiting stress proteins, including heat shock protein 70 (HSP70), p38 MAPK phosphorylation, NADPH oxidase 2 (NOX2) expression, and ROS generation ( Clinical studies found that in asthma and chronic obstructive pulmonary disease (COPD) patients, sputum H 2 S levels significantly positively correlate with neutrophil proportions, with elevation consistent with neutrophil-dominated airway inflammatory responses ( 2 S as a potential biomarker for neutrophil-related airway inflammation, revealing its dual role: exerting anti-inflammatory protective effects in acute inflammation models while reflecting neutrophil-mediated inflammatory states in chronic airway diseases

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Serrano NC, Quintero-Lesmes DC, Becerra-Bayona S, Guio E, Beltran M, Paez MC, Ortiz R, Saldarriaga W, Diaz LA, Monterrosa , et al

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Reperfusion leads to an overload of ROS and inflammatory cytokines, as well as RGC apoptosis

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The amplitudes of the NAD(P) redox dynamics were diminished by the photosynthetic inhibitor 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) ( Figure 4BE ), validating that the dynamic responses were driven by photosynthetic electron transport

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