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In a 2017 bioavailability study, methylcobalamin supplementation (1,000 mcg/day) led to 13% higher liver retention and lower urinary loss compared to cyanocobalamin, translating to sustained energy in deficient adults

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For example, in areas where iodine deficiency is still found, inadequate intake can exacerbate hypothyroid symptoms or reduce the effectiveness of medication [1]

Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production

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From there, maintenance is typically one injection every four to twelve weeks depending on diet, absorption and how the response holds