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Vitamin B12 is water-soluble and excess amounts are normally excreted through urine, providing natural protection against toxicity

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A separate investigation compared the biological activity of the GHK-Cu peptide complex with helium-neon laser-based stimulation in similar preclinical wound models

Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence