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By adopting a responsible awareness to alcohol consumption and adhering to the recommended limits, women can take proactive steps to minimize their risk of developing UFs and maintain their reproductive health [38,39]

In an endothelium-independent way, CGRP, due to its receptors, causes adenylate cyclase activation and cAMP increase, which activates protein kinase A (PKA), and this, in turn, phosphorylates ATP-dependent K+ channels, which leads to Ca 2+ sequestration mechanisms and causes smooth muscle relaxation

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Tetrahydrobiopterin (BH4) is another important cofactor involved in neurotransmitter synthesis
