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Description
Our laboratory has focused on an overlooked neurotrophic factor, hepatocyte growth factor (HGF), and found it to be more potent than BDNF when activated by angiotensin IV (AngIV)-based analogs [28]
In addition, mice subjected to an exercise regimen showed significantly increased protein and mRNA levels of MOTS-c in the plasma and skeletal muscle, as well as protein expression of SIRT1 and PGC-1 compared to mice that did not receive exercise intervention [56]
Baumeister, W
doi:10.1110/ps.8.8.1668
These findings suggest that liver disease may exacerbate AD pathology through two mechanisms: diminished peripheral clearance capacity and increased production of pathogenic proteins due to liver dysfunction
[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Wright C., Milne S., Leeson H
