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PMID: 31554795 J Am Chem Soc2024 Apr 10;146(14):9779-9789

Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men

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The animals received either vehicle (i.e., HPCD) or CB-839 (200 mg/kg) by oral gavage twice a day for 10 days, with or without a sub-efficacious dose of -lap (25 mg/kg) administrated intravenously (IV) every other day (Fig
