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Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak

While numerous randomized clinical trials substantiate the antidepressant efficacy of Rhodiola, Ginkgo, and Ashwagandha, these investigations are frequently hindered by limited sample sizes, diverse dosing protocols, variability in extract standardization, and insufficient integration of mechanistic biomarkers

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These animals and their descendants were the core of the later cattle and horse herds on the Californio Ranchos

However, this method also comes with many risks such as anaphylactic shock, unwanted side effects and the risk of infection if not performed at a reputable facility