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Symptoms of FM were previously attributed to dysfunction in central nociceptive sensory processing [15], which was explained by altered pain perception in FM patients, generalized hypersensitivity to unpleasant stimuli, altered cognitive functions, and sleep disturbances [16]

ERK is mainly implicated in cell proliferation and Rac1 in cell migration, while p38 MAPK and JNK are involved in differentiation and apoptosis