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Inhibition of key ferroptosis regulators like acyl coenzyme ACSL4, GPX4, and Nrf2 may lead to unintended consequences, including disruptions to cellular homeostasis, thereby posing potential risks to therapeutic safety

For instance, one study noted a decline in CD4 + CXCR5+ T cell frequency, particularly in severe disease (144)

Packer, L.) 121126 (Academic Press, New York, New York, 1984)

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10.1016/j.jaci.2007.01.016 [DOI] [PubMed] [Google Scholar] Klein Geltink R

Alcoholism impairs B12 status, so counsel on alcohol use