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However, high PEI efficacy is usually associated with high toxicity, which prevents its clinical application, partly due to its nondegradability [68,69]
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GHK-Cu may also promote collagen synthesis, particularly in the binding between tendon cells and bone cells
As such, HDL-Cs causality in protection from CVD is difficult to define and is somewhat controversial, mainly due to epidemiological discrepancies between the dose-response of HDL-C levels to CVD outcomes
