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When ALD advances to cirrhosis, liver failure, or hepatocellular carcinoma, where the liver loses normal function and conventional treatments are ineffective, liver transplantation becomes the most effective method to increase survival rates by providing a normally functioning liver

Furthermore, this study highlighted the increase in metallothioneins, an important piece of antioxidant machinery well known as a heavy-metal-binding protein that participates in protective stress responses [155]

Redox Homeostasis and Mitochondrial Dynamics

10.1111/jocd.13080 145 KwonS.ParkK.ParkH

doi:10.1007/s10529-013-1191-9 Cho YS (2010) A method for mass production of glutathione

To note, NRF2 regulates BRCA1 by the presence of an ARE sequence in BRCA1 promoter, creating a positive-feedback loop, with an increase of both transcripts [175]