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Overactivated myofibroblasts exhibit higher MMP activity and abnormal ECM synthesis capacity in AD, which may directly contribute to AD by producing disordered ECM and enhancing pro-inflammatory responses (108110)
doi: 10.1900/RDS.2015.12.233
10.1038/nrg700 Nat
Given the pivotal role of the system Xc -GSH-GPX4 axis in ferroptosis defense, inhibiting GPX4 or SLC7A11 has emerged as a promising strategy to induce ferroptosis in PDAC
Cai Y, Lv L,Lu T, Chen XZX, Wang X
