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Importantly, all six revSC signature genes identified in human organoids were previously reported to be upregulated in actively inflamed human intestinal mucosa 39 , underscoring the relevance of revSCs as an inflammation-associated epithelial state

All MRI data were collected using the 3 T Philips Achieva TX whole-body MRI scanner equipped with a 32-channel head coil

Systemic Overlap: Joint pain or skin issues from inflammation, highlighting the microbiota-gut-immune-brain axis

This often reduces the burping, heaviness, and uncomfortable fullness after meals

Uremic toxins such as indoxyl sulfate and p-cresyl sulfate, derived from microbial metabolism, impair kidney function and disrupt neurocognitive health via oxidative stress and neuroinflammation, highlighting the interconnectedness of these systems